Molecular Regulation of Histamine Synthesis

Molecular Regulation of Histamine Synthesis

Blog Article

Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion.Histamine is a monoamine synthesized from the amino acid WILD FLOWER histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine.Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is BioPerine still poorly understood.In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.